Cardiovascular diseases may cause accelerated brain aging. Indeed, arteries, such as the aorta or the carotid arteries, are rich in elastic fibers, allowing to smooth during the cardiac cycle the fluctuations of blood pressure (or pulsatility) further down the cerebral vascular tree. With age and disease, these arteries become stiffer, resulting in increased pulsatility downstream and leading to microvascular alterations in the brain. As a result, vascular diseases such as atherosclerosis lead to long-term cognitive deficits and even neurodegenerative diseases such as dementia or Alzheimer's. Mapping pulsatility and its evolution in the entire cerebral vascular network, from the major arteries to the capillaries, could therefore become a biomarker for diagnosing neurodegenerative diseases.