At the Acfas congresson Thursday, May 6 at 2:30 p.m., Jean will discuss the study of the link between microvascular function and metabolism in tumors using ultrasound imaging and positron emission tomography.
Positron emission tomography - computed tomography (PET-CT) is a sensitive molecular imaging modality and can be used to characterize subtle biological pathways in vivo but cannot image tissue structure. Conversely, ultrafast ultrasound (UUI) imaging uses imaging rates of up to several thousand images per second to quantitatively and at high resolution map hemodynamic, biomechanical, electrophysiological and structural parameters of tissues. In the first part of this presentation, he will describe a new preclinical scanner that records PET-CT and UUI volumes acquired simultaneously. In particular, he will show, among other things, that PET – CT – UUI makes it possible to obtain non-invasively simultaneous images of the vascular system and of the metabolism during tumor growth in mice, which has made it possible to study anti-angiogenic treatments in vivo longitudinally. Secondly, he will present recent developments in UUI making it possible to probe in depth and in vivo the architecture and function of blood vessels smaller than a few tens of microns using dynamic localization microscopy.